Everyone associated with these two teams remembers the last time they met: 2009, in the snow, with Brady throwing for 380 yards and a career-high six touchdowns en route to a 59-0 demolition of the Titans.
In fact, the Pats haven't lost to the Titans since 2002 (via NFL.com).
Tennessee has had a productive and impressive preseason and are seemingly full of confidence. Jake Locker will earn his first career start against Brady and the Pats with the idea that if the defense can slow down New England's high-octane offense, Locker will be able to work more effectively against last season's 31st-ranked defense.
New England is still a heavy favorite to win and, while the Pats will ride their usual heroes to victory, here are five Patriots who will make a huge impact on the game that might surprise some fans.