This is a highly anticipated game for many reasons. Pittsburgh will return to the same stadium that its season came to an abrupt end on last season.
It will obviously be the regular-season debut of Peyton Manning in orange and blue as well.
According to Vegas, the Broncos are currently a 1.5-point favorite, but that's probably more for home-field advantage than anything else.
It will be an intense opener for both teams, but here are five keys that should lead to the Broncos starting 1-0.