Simply put, if Arsenal are going to win the Premier League title again, then they have to get over their Manchester United jinx.
Since doing the double over the Red Devils in the 2006/07 season, Arsenal have only won two league fixtures against Sir Alex Ferguson's team.
That has to change this season.
Like it or not, United are still the team to beat, and victory over them has huge significance at any time. Last season saw Arsenal humiliated 8-2 at Old Trafford in easily the most painful defeat under Arsene Wenger.
Arsenal fought bravely in the return game in North London and were unfortunate to lose 2-1. It was a match marred by the viciously negative reaction to Wenger's decision to substitute Alex Oxlade-Chamberlain.
Watching Arsenal fans boo Wenger while standing in the very stadium he played a major part in seeing built was one of the most appalling images from last season. Arsenal have had some success against United at the Emirates, claiming three wins and a draw in six league meetings.
United have stolen a march on Arsenal in terms of summer recruitment, with the dual signing of Shinji Kagawa and Nick Powell. Yet victory on the pitch will always prove more significant.
Hopefully when the two teams meet at the end of April, this will be something of a title decider. It is simply a massive three points that Arsenal must take at all costs.