It was a pitchers duel for most of the night but in the seventh inning, the Oakland A's looked like they might pull off the victory after they broke through for a run and followed it up in the eighth inning with another run.
The Twins were shut out for eight innings and broke out in the ninth to defeat the A's 3-2.
Brian Fuentes came in to close the game for Oakland and allowed a single to the first batter he faced. He walked the next batter, Denard Span, but was then able to get two outs before he had to face Willingham.
With two outs in the bottom of the ninth and trailing 2-0, Willingham smashed a three-run walk-off home run to hand the A's their seventh straight loss.
The A's are reeling and are now 7-14 since losing Yoenis Cespedes on May 7 to a strained hand muscle.
The A's are hoping that their slugger can return soon and if all goes well he will be penciled in the lineup on Friday.
Oakland will finish their series up in Minnesota on Wednesday before having an off day on Thursday. Their road trip continues to Kansas City on Friday, hopefully with Cespedes' present, it will provide a boost this team desperately needs.