Pittsburgh Steelers general manager Kevin Colbert has indicated that Casey Hampton will return next season, but given Hampton's injury Colbert acknowledged that if the Steelers want a replacement, it will have to be an early pick (via Pittsburgh Post-Gazette).
You can't get to third down if you don't stop them on first and second...Anybody you take in the first round, you want to be three-down players. But nose tackles, chances are you aren't going to get them if you don't take them high, if they're worth anything. Can you take a guy that's not a three-down player high? Absolutely. But it's got to be unique, and they've got to be special, and nose tackle is a special part of our defense.
The most special player in this year's draft is Memphis' Dontari Poe.
Poe is a huge body at 6'4" 346 pounds and is a tremendous force in the weight room which can translate to the field.
Pittsburgh would expect Poe to anchor the center of their defensive line and he can; he commanded two blockers at the college level. He also has a favorable comparison with Haloti Ngata, but identifies Hampton as his favorite nose tackle in the league (via Pittsburgh Post-Gazette).
I've always followed him. Being one of the best, as he has been for a long time, I've followed him for a long time...He's one of the more aggressive defensive tackles this league has seen. His hand strength, once he gets his hands on you, he controls you. That's what I admire most about him.
Poe may be available for the Steelers in the first round.
Other possibilities include Washington's Alameda Ta'malu and Alabama's Josh Chapman.
Ta'malu is a second round prospect who has plenty of experience, but lacks the upside that Poe has, and Chapman is a pure run stuffer in the mold of Hampton who will fall in the draft due to an ACL injury. He is slated to go anywhere from the second to the fourth round.