United blitzed a lackluster Wigan side that will want to forget one of the worst performances of the season in a hurry, losing 5-0 to the Champions that barely had to leave second gear.
Sir Alex Ferguson needed to use an untested central-defensive partnership today due to the latest fallout of his stalwarts.
With Vidic, Ferdinand, Jones and Smalling out, Carrick and Jonny Evans were called upon to fulfill the duty, with Antonio Valencia starting at right full back with Evra taking his usual spot on the left.
With Carrick moved back, Giggs and Gibson started in the middle of the park with Nani out on the right wing and Park on the left wing.
Dimitar Berbatov was granted his second start in the Premier League this season, with his last coming via the 1-1 draw with Stoke at the end of September. He was partnered by speedy Mexican Javier Hernandez.
Anders Lindegaard was granted his second start in a row between the sticks for the Red Devils.