The Bengals are still in the hunt for an AFC Wild Card berth and cannot afford a loss against a lowly Rams team that has won just one home game this season.
However, while the Rams are playing for nothing more than pride at this point as they sit in last place in the NFC West by four games, they ambushed an unsuspecting New Orleans Saints team with a 31-21 victory in Week 8.
The Bengals have lost four out of their last five and will need to regain their focus in order to avoid an embarrassing loss against one of the worst teams in the NFL.
With Sam Bradford likely out for the Rams with a high ankle sprain, and with Andy Dalton completing just 51.5 percent of his passes over the last two games, the game will likely be determined by a defensive performance.
The Bengals have the seventh-best overall defense in the NFL (average yards per game). And while the Rams have the worst run defense in the league, their pass defense is respectable and ranks eighth in the NFL.
While the Bengals are the clear favorites, the Rams are fed up with losing and will look to gain some self-respect with an unlikely victory.