Rivers completed 24 of 33 passes for 240 yards, three touchdowns and no interceptions.
Antonio Gates was Rivers' primary target throughout the game. Gates finished with seven catches for 68 yards and two touchdowns.
The Chargers received a great performance from Ryan Mathews on the ground. Mathews ran for 114 yards and one touchdown on 20 carries.
The only good performance by a Bills player was from Stevie Johnson. Johnson hauled in four catches for 116 yards.
Ryan Fitzpatrick was picked off twice in the game, including one pick six by Steve Gregory.
The Chargers still have a chance to make playoffs if they win out and the Broncos lose the rest of their games.
The Bills are now eliminated from playoff contention.
Final score: Chargers 37, Bills 10
Michael Walkusky is a featured columnist on Bleacher Report. Follow him on Twitter