With Missouri quarterback James Franklin being a heavy contributor to the team's running game, the Tigers have the 12th ranked rushing offense in the FBS, running for 235.7 yards per game.
Missouri was led by sophomore running back Henry Josey, who was propelled into a starting role after the Tigers were hit with a series of injuries. Now, with Josey's knee injury, the Tigers will have to depend on a running back by committee that features Kendial Lawrence and De'Vion Moore.
Missouri's prolific running attack will face North Carolina's 14th best rushing defense. The Tar Heels only allow 106.17 rushing yards per game.
This game could come down to whether the Missouri running attack can get going.