Against lowly, but game, Aldershot in the Carling Cup, Sir Alex fielded a completely different lineup than the one City thrashed.
And although it was against lower-level opposition, the victory was a soothing tonic for the beleaguered United side.
But the weekend brings with it Premiership football once again, and Everton is never easy opposition.
Ahead of the game, considering the poor performances from the Manchester derby and the good performances out of the Carling Cup, Sir Alex has some decisions to make as to who he sends out against the Toffees.
It's never an easy thing for a young 'keeper when you let six goals past you. It's even harder when it's your first year after replacing a club legend and you've had your fair share of howlers early in the season.
With Anders Lindegaard waiting in the wings, this next game is an important one for David de Gea, perhaps the most important match of his young United career.
Cutting a forlorn figure at the final whistle against City, how de Gea responds to the loss will speak volumes about both his psychological makeup and his chances of growing into Edwin van der Sar's gloves.
De Gea does have some things going for him though. None of the goals he allowed were howlers, having been mostly the fault of the defenders in front of him. He is still a great shot-stopper and he has shown remarkable courage in recovering from previous mistakes.
Dropping him now might do more harm than good in the long term. Sir Alex must allow his young 'keeper to recover, and sticking him straight back in goal is the best way to let him know that he still has faith in him.
Unlike the case of David de Gea, Patrice Evra actually is partly at fault for United's lackluster defense.
On the basis of his play during the City game, it looks like the early-season success that United enjoyed might have gotten to the Frenchman's head.
His performance was full of runs up-field that led nowhere, and he got caught in the City half too often for a defender of his stature. He has to remember that he is a left-back, not a left winger.
I may be a bit harsh, but Evra needs to have a seat for at least one game and think about his place on the team. He's supposed to be one of the leaders, after all.
Thankfully, United have a talented young left-back waiting to seize his opportunity. Fabio da Silva played a great full-back against Aldershot, and he's primed to carry that momentum into the first team.
Considered by some to be more talented than his more established twin brother Rafael, I think it's time to give Fabio a long look in the Premiership.
Tom Cleverley, one of United's brightest young guns in the early season, made a welcome return to the midfield in the match against Aldershot.
Paired with Park Ji-Sung, the young Englishman looked like he never left, picking up where he left off with an assured performance that begs a start in the next game.
Although Park and Cleverley fed off each other well, for the match against Everton a bit more steel is needed in the center of the pitch, which is where Darren Fletcher comes in. In earlier games, when Cleverley played with Anderson he was more of a stopper, allowing Anderson to move up more often.
Being paired with Fletcher, the most defensive-minded of United's first-team midfielders, should allow Cleverley the freedom to be more of an attacking midfielder, where he can showcase his creativity and passing skills.
Doing so should give Sir Alex a bit more insight as to how January's transfer window should go. As for Anderson...well, a spell on the bench until he reclaims his form is in order.
Nemanja Vidic was absent from the derby match, and boy was he missed.
With Rio Ferdinand inexplicably rendered virtually useless against the rampaging City, it became clear just how much United's solidness in defense rests on the Serbian's shoulders.
After getting a run out against Aldershot, it's time for Vidic to reclaim his position as the rock at the back.
As previously mentioned, Ferdinand had a shambolic game. Like Evra, he needs to be dropped for at least a game to let his disappointing performance sink in. And with Jonny Evans out suspended (and playing poorly anyway) and Chris Smalling doing well at right-back, Jones would be the best choice to partner Vidic.
A guaranteed future fixture on the England national team and a very similar player to Vidic himself, Jones would give the back line the athletic and tough centre-back that it lacked against City.
The best tonic for a 6-1 drubbing is to score goals. Bags of them.
With poor Danny Welbeck looking slightly out of his element against City, it's time for Chicharito to make his way back into the starting lineup.
Perhaps the most clinical of United's finishers, the young Mexican will be hungry to prove to Sir Alex that he deserves to start every match. And he's developed a good enough relationship with star man Wayne Rooney to make that happen.
Welbeck is still an excellent striker and the wave of the future, but Hernandez should start this game right from the get-go instead of coming in when United is chasing the game, as he did against City.