Jerome Harrison was traded back to Philadelphia, where he played in 2010, but the trade fell through after doctors discovered a tumor on Harrison's brain.
In what was undoubtedly the most successful failed trade in NFL history, Detroit Lions running back Jerome Harrison was turned away from the Philadelphia Eagles after team doctors discovered a tumor on his brain.
The trade would have sent the 28-year-old Harrison and an undisclosed 2013 draft pick to the Eagles in exchange for running back Ronnie Brown, according to ESPN's Adam Schefter.
Harrison is now being treated for the tumor and is expected to recover fully, but will likely miss the remainder of the season, according to Schefter's report.
The failed trade now leaves the Detroit Lions with major question marks in their backfield.
Rookie running back Mikel Leshoure went down in training camp, and the Lions were left with speedster Jahvid Best to carry the rushing load in 2011.
Best suffered the third concussion of his career last week in Detroit's loss to the San Francisco 49ers, however, and now, the Lions are scrambling to patch together a serviceable NFL backfield.
The acquisition of Brown would have given the Lions a proven veteran to hand the ball off to for the rest of the season, or at least until Best's return.
What should the Lions do now?
Now, though, Detroit will have to rely on 10-year veteran Maurice Morris to keep opposing defenses honest.
Morris has 20 yards on just nine attempts in 2011, and is best known by NFL fans from his time with the Seattle Seahawks from 2002-08.
The only other option behind Morris is former LSU bruiser Keiland Williams, who is averaging 2.6 yards per carry this season.
The Best injury has no doubt cast a huge cloud of doubt over the upstart Lions after their incredible 5-0 start, but the losses of Brown and Harrison after the developments of the physical now leave Detroit in desperate need of help.
The Lions were already the 25th-worst rushing team in the NFL before all of this, but they'll now have to fight for a playoff spot with a make-shift backfield.
The good news: The Green Bay Packers did just that last season, and Tiki Barber is still available.
Follow Bleacher Report Featured Columnist Patrick Clarke on Twitter @_Pat_Clarke