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In Frank Mir's case, this fight allows him to continue his quest back to a title shot. However, he would need to be careful here.
If he losses against Nelson, he would pretty much be relegated to nothing more than a permanent gatekeeper.
While the Las Vegas native would probably never get bounced from the UFC, his plans to get back on top would be highly unlikely.
A decisive victory - and I must emphasize the word decisive in Mir's case - would put him on a continuous pace back to a potential title shot.
Here are the following options where Mir could go in after a win :
1 - Brock Lesnar: This would be an excellent way to end the triology. If Mir can somehow beat Lesnar, it will finally allow him to conquer the demons he's been facing in his own mind after suffering a vicious loss to the former champ at UFC 100.
2- The loser of the Velasquez - Dos Santos fight some time in the late winter or early spring. If he's able to take that opponent down, then he would be in perfect line for a title shot.