Super-subs Dan Gosling and Jack Rodwell struck late on as Everton record a 3-1 victory, their first over title chasing United since 2005.
Gosling, who had only been on the pitch for six minutes stuck out a right leg to convert a Steven Pienaar cross in front of the Gwladys Street end. Rodwell, 18, put the contest beyond doubt in added time as he drove at a fatigued United defence before drilling the ball past a helpless Van Der Sar.
The Champions grabbed an early lead as a Valencia cross found it's way to the feet of Dimitar Berbatov, who showed great close control before smashing in a shot via the underside of the bar.
But Everton immediately levelled the tie in emphatic style after Bilyaletdinov’s strike left Van Der Sar powerless as it swerved just inside the post.
This result was United's sixth defeat of the campaign; they were the last side to lift the Premier League trophy after suffering this many setbacks within one season.
United boss Sir Alex Ferguson expressed his concern, blaming his team's European duties as a possible reason for his team's lack luster performance.
“We were well beaten, simply that, in the second half we were out-played,” said. "Maybe we left something in Milan in midweek, certainly there was a lot of tiredness in the team.'
“It’s a bad result for us, at this time of year you can’t afford to have results like the one we had today. Obviously we hope others drop points too and that can happen the way this league is.”
The Blues, however have won their last five home games and now have their sights firmly set on the European places on offer, as they recorded only their fourth victory over the Champions in the previous 36 meetings. Blues boss David Moyes, hailed his players and their recent form.
“It was a great team performance, and there was a great work ethic amongst the players,” Moyes said. “We’re starting to get back to the way we’ve been for the past year or two. Now we can start looking up (the league table) instead of down.”
Moyes also praised his match winners adding "They’ve both got talent and great potential to go on with age and experience, a bit like Wayne (Rooney) at times.”
David Moyes also played down rumours, insisting that Jack Rodwell's future is at Everton despite the ever growing speculation surrounding the young midfielder.
In his post match interview Moyes told BBC Radio 5 Live's Sportsweek programme that similarities between the emergence of Rodwell and Wayne Rooney six years ago cannot be drawn.
Moyes believes the club are in better equipped in holding talent such as Rodwell, insisting the club's over all position has improved since Wayne Rooney left for Manchester United in 2004
He said: "We weren't ready when Wayne came on the scene.'
"We're ready for Jack Rodwell and our team is good enough to carry a Jack Rodwell and keep bigger suitors away.'
"There's been quite a lot of attention towards Jack Rodwell for a while," Moyes continued.'
"But strangely enough, it was Wayne that worried me a lot more. It doesn't worry me quite so much with Jack because we've been through it before."
After this weekend saw the young midfielder express his talents against title chasing United it looks like Moyes will have a fight on his hands keeping Rodwell at Goodison Park.