With so many injuries at such a key position, you may be scrambling to find a capable fill-in.
There are even a couple of old, familiar faces that made their way back into the fantasy picture during Week 11.
LaDainian Tomlinson-RB-San Diego Chargers
LT certainly looked like his old self last week against Philadelphia, rushing for 96 yards and a pair of touchdowns.
He faces another solid defense this weekend against the Broncos, but maybe he's found the fountain of youth.
He'd be deserving of a start if you have him.
Chris Wells-RB-Arizona Cardinals
Beanie broke out last week against Seattle and had his best game as a pro by far, rushing for 85 yards and two touchdowns.
The Rams don't appear to be as bad as we thought, but the Cardinals should be able to get ahead early in the game, meaning they'll be running the ball more and more during the latter stages. That's when Wells could do his damage.
Why not plug him in and give him a shot?
He's run for over five yards per carry over the past three games.
Jonathan Stewart-RB-Carolina Panthers
Stewart's 82 yards and two touchdowns looked almost identical to those numbers of Wells in Week 10.
Stewart has tremendous value once Carolina gets down around the goal line, so he's a big-time threat to visit the end zone.
Keep in mind, if you're going to play him, you'll have to put him in soon. Carolina plays Miami on Thursday night.
Sidney Rice-WR-Minnesota Vikings
Rice is averaging 128 yards receiving per game over his past four.
Last week, he went wild for 201 yards on just seven receptions.
While he didn't find the end zone, it's clear that he's become Brett Favre's No. 1 passing option.
With the Vikings facing Detroit Sunday, expect him to do some damage.
Joseph Addai-RB-Indianapolis Colts
Addai has put together two solid weeks in a row, scoring four touchdowns.
While his yardage isn't through the roof, the fact that he's getting into the end zone makes him a worthy fantasy option.
Donald Brown-RB-Indianapolis Colts
The recent success of Addai combined with a nagging shoulder injury has kept Brown's production at a minimum.
While he'll get a few touches, it's unclear if he'll actually get enough to make much of a difference.
He was effective earlier in the season, so don't cut him, just don't expect much out of him right now.
Matt Ryan-QB-Atlanta Falcons
It's been tough sledding recently for last year's Offensive Rookie of the Year.
The Falcons are struggling and are headed into a hostile environment (Giants Stadium) to face a Giants team that will be desperate for a win.
Play him if you must, but don't be surprised if he doesn't give you much of a boost.
Joe Flacco-QB-Baltimore Ravens
Flacco, since starting the season with such explosive numbers, has been quite pedestrian in recent weeks. He had a no-touchdown performance against the hapless Browns last Monday night.
Needless to say, the Colts aren't the Browns. It could be more of the same from Flacco Sunday.
Greg Jennings-WR-Green Bay Packers
Jennings isn't just a faller for this week, he's been a faller all season long.
Green Bay's No. 1 deep threat hasn't gotten many touches at all this season because the Packers' offensive line has had so many problems keeping pass rushers away from Aaron Rodgers.
He only had four catches for 45 yards last week in a game the Packers won.
Until he does something, I would keep him on the bench.
Marshawn Lynch-RB-Buffalo Bills
Lynch has just one rushing touchdown in the five games he's played since returning from his season-opening, four-game suspension.
Fred Jackson has been flat-out better all season long and the Bills don't have much reason to favor Lynch nowadays.
While I wouldn't cut him, I wouldn't play him right now, either.
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