The victory saw the Red Devils trim the gap to leaders Manchester City to 13 points, while January signing Alexis Sanchez opened his account for his new club on his home debut.
Newcastle, meanwhile, will be out for a win that will propel them away from the relegation zone. The Magpies are just a point off the bottom three and are without a top-flight victory since New Year's Day.
Here's a look at how you can watch the game, team news and a preview of Sunday's clash.
Date: Sunday, February 11
Time: 2:15 p.m. GMT/9:15 a.m. ET
Venue: St. James' Park, Newcastle
TV Info: Sky Sports (UK), NBC (U.S.)
Newcastle's new loan signing Islam Slimani could be fit enough to make his debut after training with the first team for the first time on Wednesday, according to Sky Sports News.
Manchester United are still without midfielder Marouane Fellaini after he underwent knee surgery and is expected to be out for six weeks, the club have confirmed. He joins Eric Bailly and Zlatan Ibrahimovic on the injured list, with Jose Mourinho hopeful the latter duo will be fit before the end of February, per David McDonnell at the Mirror.
Jose Mourinho's lineup for Sunday's game will be interesting to see as the Red Devils boss opted to drop Paul Pogba from his team last time out. The midfielder was replaced by 21-year-old Scott McTominay, who played the full 90 minutes, while Pogba was a second-half substitute.
Squawka Football showed how influential Pogba has been this season:
Squawka Football @Squawka
Was Mourinho right to drop Pogba? It’s clear what Pogba brings to the table: creativity and flair. A key creator from deep, only Juan Mata (37) has created more chances than Pogba (30) for United this season, though the Frenchman leads the way with nine assists. https://t.co/tY89phXv8p
It would be a surprise if Pogba did not return to the team, and he will have fond memories of Newcastle having scored against them in the 4-1 win at Old Trafford back in November.
However, United have struggled to get the balance right in midfield this season, and summer signing Nemanja Matic has looked jaded after a bright start to his United career.
Samuel Luckhurst at the Manchester Evening News said the team may only need two midfielders against Newcastle:
Although the midfield has not clicked at times, the arrival of Sanchez has strengthened the United attack, and he was named the man of the match against Huddersfield:
The Chilean has added energy and drive to Mourinho's side, and that will be needed against a Newcastle team battling relegation.
Benitez's team have drawn their last two games, against Burnley and Crystal Palace, but there will be a sense of frustration as they went ahead in both matches, only to be pegged back.
Newcastle have suffered from a lack of goals this season, and they will hope Slimani will be the man to fire them out of trouble. Ryder showed his goalscoring record in the Premier League:
The arrival of Kenedy, on loan from Chelsea, has also boosted Newcastle, and the Brazilian has made a good early impression at the club. Scouted Football showed how he fared on his debut against Burnley:
The duo will need to be in top form if they are to trouble United, who have the best defensive record in the Premier League with just 18 goals conceded in 26 games.
However, the visitors will be favourites to win on Sunday, and their extra quality in attack, with Sanchez, Romelu Lukaku and Anthony Martial all available, may prove to be the difference between the two sides.