Cesar Delgado's 91st-minute winner in front of the kop last night may well have killed Liverpool's season as early as Oct. 20.
I had written earlier in the week how Benitez had no choice but to win against Lyon knowing they faced back-to-back away ties in the group before taking on Fiorentina in the final game.
Throughout Benitez's reign at Anfield, his teams have always managed to drag themselves out of danger, but the postmatch interview from Jamie Carragher, a Liverpool stalwart, was downbeat and the face of Steve Gerrard on the bench was of thunder.
He had talked throughout the summer of how close he felt Liverpool was from pushing United that one bit further in the title bid; defeat on Sunday will see the Reds having already lost five out their opening 10 games.
As for the Champions League, Liverpool will be lucky to finish third in the group just in order to prolong their European campaign into the new year in the Europa League.
I mentioned how possibly Kenny Dalglish could help out his club by coming in until the end of the season if the men at the top decided enough is enough with Benitez, who himself is almost at a complete loss as to how to explain this dreadful sequence of results.
I believe this type of move is needed to engulf the fans who booed their team off the pitch at the final whistle. Benitez has lost the dressing room, there is no doubt about that.
Newcastle United and Leeds United are two teams who Liverpool are scarily emulating with the money men at Anfield refusing to rule out ever having to sell the club's best assets to keep the financiers happy.
One positive that can be taken out of last night's farce is the performance of Martin Kelly at right back.
He looked confident, and in his Anfield debut looked to move forward, but as luck would have it he was forced off injured just after the Lyon leveller. Kelly was later voted the man of the match by fans, but how much does that tell you about the other players involved?
Football is a funny game; in a month's time, the Reds may have won six in a row and may well be only a few points off top in the final 16 of the champions league.
However, this will not happen unless confidence is lifted, and perhaps it will take the departure of Benitez to re-charge this under-performing footballing powerhouse.