Real Madrid continue their La Liga campaign on Saturday afternoon, with Villarreal the visitors to the Santiago Bernabeu.
Zinedine Zidane's side were held by Celta Vigo last time out in the league and are now 16 points behind leaders Barcelona, although they have played a game less then their rivals.
Villarreal, meanwhile, head to the Spanish capital knowing a victory will move them to within a point of Los Blancos.
Date: Saturday, January 13
Time: 3:15 p.m. (GMT)/10:15 p.m. (ET)
TV Info: beIN Sport (U.S.)
Real Madrid are still without captain Sergio Ramos, who has suffered a setback in his recovery from a calf injury, per Reuters.
Karim Benzema is also sidelined with a hip problem and is not expected back until later in January, per Marca's Pablo Polo.
Villarreal will be without defender Victor Ruiz due to suspension and remain without long-term absentees Bruno Soriano, Roberto Soriano, Nicolas Sansone, Andres Fernandez and Ruben Semedo.
The visitors will also have to make do without top scorer Cedric Bakambu, who is heading to China, so will look to Carlos Bacca for goals against Madrid.
Zidane is coming under scrutiny due to Real Madrid's disappointing defence of the La Liga title, in which they are so far behind rivals Barcelona.
Real look a shadow of the side that retained the UEFA Champions League trophy in June, with key players Cristiano Ronaldo and Karim Benzema out of form while Gareth Bale has struggled with injury.
The club also appears to have lost some strength in depth after Alvaro Morata and James Rodriguez moved on in the summer.
However, Zidane has said he does not plan to strengthen in the January transfer window and he trusts his current squad, per beIN Sports.
Madrid have been boosted by the return to fitness of Bale, who started and scored twice in the draw against Celta.
ESPN FC's Dermot Corrigan said the Wales international looks in good shape after a lengthy spell out:
Dermot Corrigan @dermotmcorrigan
Not to say that Bale and Ronaldo working as a partnership / not sure they've linked up at all. But Bale looks razor sharp and fully fit.2018-1-7 20:32:06
After the game, Zidane also said the team held a meeting to talk about their situation, per Corrigan.
It's therefore possible the manager may look to make changes for the Villarreal clash, but improvements will be needed after Madrid looked so jaded against Celta.
Villarreal were also held last time out in the league, when they conceded an 86th-minute equaliser in a 1-1 draw with Deportivo La Coruna.
It was only their fourth league draw of the season and leaves them in sixth place in the table ahead of this weekend's round of fixtures.
The Yellow Submarine will also be weakened by the loss of top scorer Bakambu, who is set to join Chinese Super League side Beijing Guoan, per European football writer Andy Brassell:
Andy Brassell @andybrassell
Cédric Bakambu to Beijing Guoan already one of the more eye-popping deals of Jan so far. Now @francefootball reports Beijing end up paying €74m w/tax obligations & he’ll earn €18m/year pre-tax2018-1-10 13:52:33
However, the club have moved quickly to replace Bakambu with forward Roger Martinez, per Marca's M. A. Rodriguez.
The Colombia international was named on the bench for the Copa del Rey clash against Leganes on Wednesday but could feature at some point against Real Madrid.
Villarreal have the players to cause the hosts problems, but Zidane will demand a response from his side after a difficult spell. And with Bale back and in form, Real may just have the extra firepower to secure all three points.