Indianapolis Colts vs. Jacksonville Jaguars: Betting Odds, Analysis, NFL Pick

The NFL returns to London on Sunday as the winless Jacksonville Jaguars take on the Indianapolis Colts in a Week 4 battle between AFC South rivals at Wembley Stadium.

The Jaguars have been an early-season disappointment with three consecutive straight-up losses, extending their current SU losing streak to six games.

The Colts are coming off their first SU win of the season, a narrow 26-22 victory over the surprising San Diego Chargers as 1.5-point home chalk, and will be looking to avenge a lopsided 51-16 loss to Jacksonville in Week 14 of last season.

Point spread: The Jaguars opened as 2.5-point favorites. The total was 49.5 early in the week.

Odds Shark computer pick: Jaguars 22.6, Colts 22.4 (NFL picks on every game)

Why the Colts can cover the spread

Indianapolis is off to a slow start again this season but will be looking to reverse its fortune by continuing its winning ways against division rivals. The Colts are on a sparkling 20-3 SU run against AFC South opponents, including a 6-1 SU record against the Jaguars.

Quarterback Andrew Luck showed no adverse effects from a shoulder injury that had left his status in doubt ahead of their win over San Diego, throwing for 331 yards and the game-winning touchdown.

Luck has thrown for eight scores in five straight wins over Jacksonville, with the Colts holding the Jaguars to just 8.6 points per game in those contests, covering as favorites of six or more points four times.

Why the Jaguars can cover the spread

Although the Jaguars have struggled early on, quarterback Blake Bortles continues to show his stuff as a bona fide NFL pivot, twice throwing for over 320 yards and finding the end zone on five occasions.

Bortles must make adjustments to avoid repeating last week's three-interception performance in a 19-17 loss to Baltimore but will face a far more porous Colts pass defense that has surrendered more than 300 passing yards per game this season. That positions the Jaguars to improve on last week's 6-for-16 third-down conversion rate.

The Colts, meanwhile, were a brutal 2-for-9 on third downs last week and will have to contend with a stingy Jaguars pass defense that held both the Ravens and Green Bay to fewer than 200 yards earlier this season.

Smart pick

Both Luck and Bortles possess the ability to blow this game open, with the advantage going to whichever team's offensive line shows up.

However, it took almost four full quarters for Luck to find the end zone last weekend, while the Jaguars have eked out just 15 points per game in their past four outings. Take the Jaguars to pick up a slim SU and against-the-spread win in their home away from home, with the point total playing under.

Betting trends

• The Colts are 6-1 SU and 5-2 ATS in their last seven games against the Jaguars.
• The total has gone under in eight of the Colts' last 10 games against the Jaguars.
• The Jaguars are 0-5 SU in their last five games against teams with losing records.

All betting information courtesy of Odds Shark. All quotes gathered firsthand unless otherwise noted. Check out Twitter for injury and line movement updates, Odds Shark on YouTube for picks and analysis, or download the free odds tracker app.