The two guys that may have the biggest influence in the final score could be tight ends Jason Witten and Martellus Bennett—and not for the reasons you may think.
The Giants secondary is banged up and depleted (starting cornerback Aaron Ross is out), and the Cowboys will be looking to take advantage of that.
Jason Garrett has introduced the two tight end formation this season, and it was obvious that Tampa Bay had problems with the mismatches this created.
There is no one on the Giants roster that can handle either one-on-one in pass coverage, so look for Cowboys quarterback Tony Romo to attack the seams, as well as crossing routes away from the flow of the play, tossing it back across the field to his athletic tight ends.
That's the obvious reason. Now to the things that will affect the game but won't show up in the box score beside Witten's and Bennett's name.
With Justin Tuck and Osi Umenyiora, the Giants have the best defensive end duo in the NFL.
The Cowboys offensive tackles, Flozell Adams and Marc Colombo, have no chance blocking them one-on-one, and that is where Witten and Bennett are crucial.
Out of the two tight end set, Witten and Bennett can chip the star defensive ends, which will afford Dallas a couple major things.
First, Dallas can run the ball right at Tuck and Osi, and wear them down.
Having two guys beat up on you for 60 minutes makes for a long night.
A tired Tuck and Osi turns those two and three-yard rushes into 20 to 30-yard bursts in the 4th quarter.
The chip blocks by Witten and Bennett also gives Romo a moment or two longer to find his receivers. This is huge, even for the most elusive quarterback in the NFL.
Finally, when Witten and Bennett do go out in their routes, expect more than one guy to be guarding them.
This should open it up underneath and in the flats for Marion Barber III, Felix Jones and Tashard Choice.