The Bucs' defense led the way with five sacks and three takeaways, while the starting offense finally found their groove, helping the Bucs build a 24-0 halftime lead.
Josh McCown completed 13 of his 16 passes on the night for 112 yards, including a 24-yard touchdown strike to rookie first-round wide receiver Mike Evans. Doug Martin showed glimpses of his rookie season, gaining 65 total yards and finding the end zone on a one-yard run to open the scoring.
A Michael Johnson strip-sack was scooped up by Clinton McDonald, who rumbled 17 yards for a Tampa Bay score. The Bucs scored 14 points off turnovers, holding the Bills to just 82 yards of total offense in the first half.
Dashon Goldson set the tone early, intercepting EJ Manuel on the first drive of the game.
Tampa Bay's depth continues to be a concern, as the Bills put the ball in the end zone twice in the third quarter. Buffalo did leave its starters in longer than did Tampa Bay, and Manuel clearly fared better against the Bucs reserves.
Tampa Bay still has a ways to go before its ready to beat the likes of Carolina and St. Louis—their first two regular season opponents—but tonight's victory was a sizable step in the right direction.