The youngest member of Meyer's squad is by no surprise also the most promising up-and-comer, but Handre Pollard's first move on a major international stage will be daunting nonetheless.
Beating out the likes of Morne Steyn and Pat Lambie, the 20-year-old will start at fly-half for the hosts on Saturday, and Sanchez has the job of limiting the influence of one of the most tactically shrewd, young minds in the game at present.
Meyer spoke to SuperSport earlier in the week, voicing yet more admiration of the potential superstar he's got on his hands:
He is only 20 years old, but he is a very mature 20 year old. I’ve watched him since he was a 15-year old and he has always impressed me.
What makes him an unbelievable prospect, and he knows there still is a lot of hard work ahead. The great thing about him is – and you don’t find a lot of this – he has an unbelievable attacking game, he is good enough to have a good tactical game. You don’t find that a lot in a number of 10s. Most of them are good tactical fly-halves or they are running fly-halves. Handre is almost too big and tall for 10, and that will always be his challenge, especially with his speed and reaction to kick under pressure.
But he is mentally tough and the other thing that impresses me is his leadership quality. I always believe you have to have a 10 that the players trust, a 10 that the players know is cool-headed and don’t mind if he takes charge of the calls because they trust him. They know he is cool and calm under pressure.
Despite Meyer's words being nothing short of the truth, Sanchez's one advantage is the experience of having played on this kind of occasion more than his opposite man.
It will be up to the 21-times capped No. 10 to ensure Pollard's impact can't be felt at its most extreme, and to do so, he too will have to showcase a broad range of qualities.
Pollard's blend of running and kicking means that Sanchez will be expected to keep a close eye on line speed, judging where and when a high press or a slower mark is needed in order to counter South African movements.
Despite being so young, Pollard is very much the key to the Springboks' potential unlocking of the Pumas defence, and Sanchez will need all the help he can get from his loose forward in ensuring the starlet gets as little time on the ball as possible.