South Africa have a thriving horde of options on their flanks, but among the cream of the crop sits Willem Alberts, whom Meyer has shown to be among his favourite options since taking the team's helm.
Regardless of where he plays in the loose forward positions, the 120-kilogram mass of Sharks force gets a job done with specific instructions: hit and run.
His handling may not be on the same level as other back-row bastions of the world's elite, and one can debate his worth at blindside, but as a player, Alberts is a terror for opponent defences to deal with.
Called up as cover for the injured Matfield, Juan Smith will get the chance to once again prove his mettle as a Springbok this summer, providing he can squeak his way in front of those other flank stars in the squad.
The 33-year-old has proved to be a talismanic presence at Toulon, particularly in their late run to a domestic and European double this year, but the Rugby Championship will be a more intense test of how well he's recovered from injury.
If Alberts is a sign of the Sharks' back-row talent slowly migrating out of the national team, Marcell Coetzee is very much a sign of the good things to come from Natal contributions.
The 2014 campaign was something of a coming of age for the 23-year-old, who doesn't allow a lack of experience to prevent him from competing against the best of the Southern Hemisphere.
At the breakdown, Coetzee regularly makes a nuisance of himself in disrupting enemy retention, but he also has a scoring streak to his name, particularly dangerous in the close quarters.
Coming all the way from England's West Country is a journey that Francois Louw will be accustomed to, but this summer won't be nearly as disrupted as the Bath man has grown used to.
South Africans will be hoping that smoother journey will benefit a player whom some are backing to captain the squad during their Rugby Championship opener against the Argentinians, a sign of his lead-by-example nature.
The blindside has shown on the club level this past Premiership season that his workhorse attitude is as strong as ever, and he sits among Meyer's most useful terriers in wresting possession from the enemy.
Making his debut under Meyer in late June, Oupa Mohoje's worth as an international player is still under scrutiny, especially considering that debut came after just seven games in Super Rugby.
Meyer evidently sees something promising in the 24-year-old, who has made his way to the top through less conventional means but is nonetheless grasping his chances as they come.
All that being said, the blindside has the potential to be monstrous for the national team, but potential is all it is at present, yet to truly prove himself along the same lines of some team-mates.