As a freshman Hughes returned an interception 72 yards for a touchdown. He was awarded the Bob Simmons award for the best freshman on the team. As a sophmore Hughes started 11 of 12 games.
As a sophmore Hughes led the pac-10 in passes defelected. He ranked 16 in the nation in interceptions, with a total of five, and returned an interception for a touchdown. Hughes was starting to become a draft prospect.
As a senior in 2006, Hughes was named Pac-10 defensive player of the year, an won the Ronnie Lott award. He was a first team all american and recorded an amazing eight interceptions. Huges had multiple multiple interception games.
Hughes dominated in the pro's with his great ball skills and instincts, but he was not fast enough to be a top cornerback in the NFL. Hughes was drafted by the Colts in the third round in the 2007 NFL draft.
As a rookie in 2007, Hughes recorded 14 tackles and two pass break ups in ten games. Hughes did record an interception in his rookie season... in the preseason. Hughes was placed on IR after week twelve of his rookie year.