Spain is the defending World Cup champion and a significant betting favorite as they open Group B action facing Holland, the team they beat in the final of the 2010 World Cup final.
However, the Netherlands played well that final and could be excellent value here to come up with a draw against Spain this time around.
Sportsbooks monitored by OddsShark.com have Spain at slightly better than even odds with the Netherlands at 4-1 and a draw line of roughly 12-5.
Some have even pointed to Chile as an upset group winner here, and some of the betting volume in group action suggests that some professional bettors believe the golden age of Spanish soccer may be coming to a quick close.
Spain is led by their great midfield, which may be the best in the world with Cesc Fabregas, Andres Iniesta and Xabi Alonso. They also boast a great defense led by 2010 final hero and Real Madrid keeper Iker Casillas.
While the Spanish have two clean sheets in their last two World Cup tune-ups, neither were facing World Cup-bound teams.
Spain will be contending with a Holland offense led by Robin van Persie and Arjen Robben, and attacking midfielder Wesley Sneijder. The defense is the supposed weakness of the squad, but in their last two World Cup tune-ups, they kept a clean sheet, including beating a solid Ghana team.
While Spain striker Diego Costa has been cleared to play after dealing with an injury late in the La Liga season, the squad does not have a great attack. In their three friendly matches this year, they have not conceded goal but have only scored five. In their only real test in those matches, they only scored just once against Italy.
The Spanish tend to dominate the time-of-possession game with their great midfield play, but the Dutch played that strategy well in the 2010 final and will do so in this match.
Spain is vulnerable on the counter-attack, even with their great defense, and Van Persie and company will take advantage of that in this match.
Spain will find the back of the net once in this match, but so will the Dutch, who will take away one point with the draw in the biggest group match.
Spain vs. Netherlands prediction: 1-1 draw
Odds, stats courtesy of Odds Shark and WorldCupOdds.net