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Most of Santos' serious selection dilemmas involve his midfield.
Giorgos Karagounis and Katsouranis are unlikely to start together. Assuming he sticks with his preferred 4-3-3, Santos is likely to select three from Karagounis, Katsouranis, Giannis Maniatis and Alexandros Tziolis. In the friendlies, Katsouranis has been given the nod more often, barring the more experimental line-up that Santos chose against Nigeria.
Essentially it is a choice between the vast experience of Karagounis and the very slightly less vast experience of Katsouranis. Katsouranis is "only" 34 years old (although he turns 35 during the tournament) and Karagounis has recently turned 37. Karagounis has greater ability on the ball, but Katsouranis provides greater physical presence.
Playing Karagounis may be something of a signal that Santos intends Greece to see more of the ball, and play in a less reactive fashion, but that seems a long shot.
And speaking of long shots, the potential inclusion of the creative, attack-minded Panagiotis Kone in place of either Maniatis or Tziolis would represent a very clear signal of intent from Santos. Kone started and scored against Bolivia, and with goals at such a premium for Greece, perhaps Santos will take a gamble few are expecting.