It promises to be a tough fixture for the Reds, who have lost to the Saints twice in two games since Mauricio Pochettino was appointed as manager last year.
Southampton’s brand of relentless, physical and energetic football is complemented by a quick, strong and young midfield core, and are perfectly equipped to exploit Liverpool’s shaky defence.
But with their four-goal haul against the Swans last week, Brendan Rodgers’ side have overtaken Manchester City as the league’s highest-scoring team so far this season.
Here is our starting XI for Liverpool at St. Mary’s Stadium this Saturday. Let us know your picks in the comments below.