This match has effectively become the battle for "the Wooden Spoon" as the Six Nations' bottom two teams face off against one another in the Stadio Olimpico.
Italy host a dogged Scotland team that has lost its first two matches against Wales and England. The Italians will feel they can compete with this Scottish team, even though they were recently soundly beaten by France in Paris.
Neither team can have any serious hopes of discernible success this year, so the match represents for both teams their best opportunity to taste some glory in 2014.
When: Saturday, Feb. 22, at 1:30 p.m GMT/8:30 a.m. ET
Where: Stadio Olimpico, Rome, Italy.
TV Info: Live on Live on BBC One and HD
Live Stream: BBC iPlayer
Who will get the Wooden Spoon in 2014?
As the current table shows, both teams have performed poorly, Italy conceding 53 points in their two games and Scotland haemorrhaging a disappointing 48 points.
The Italians lead the Scots by way of points difference. Scotland have only managed to score a paltry six points during the tournament.
Neither nation wants the indignation of earning the title of this year's worst team, but there is very little to choose between the sides. They are both miles behind the other four nations in terms of quality and match-winning ability.
Here is the current table, which highlights both countries' plight:
Are Italy favourites to beat Scotland?
On paper it would appear that the Italians are in pole position for the victory in the match, with Scotland's statistics being so poor and the home team in their very own Roman fortress. However, Italy did concede heavily against their opponents in their last encounter.
Italy head coach Jacques Brunel said, per BBC Sport:
Last year we conceded 34 points at Murrayfield; that's something we have to take into consideration. Recent results haven't been going Scotland's way, but they're one of the teams we seem to have most difficulty with. They have character and always play with determination. They will be tough opponents.
We have worked as always on the defence, which I think has improved from last year even if there are still too many individual errors. We still have to learn to take control of games when we can. In Wales, we conceded too many points at the beginning, and in France we created a lot without finishing off as many as we should. But creating chances of scoring a try is something positive.
Despite Brunel's cautious words, this is their best opportunity to win and celebrate a rare Six Nations triumph. Scotland will be laid low after their defeats, and by their conclusive inability to convert opportunities into points.
They will travel to Rome nervously, knowing that their opponents have enough to rock the status quo and take the win. Being rooted to the bottom of the Six Nations is not a place Scotland thought they would be.
Who will win this year's Six Nations Wooden Spoon?
The Italians have threatened to improve for years and this could be a stepping stone for them.
To beat one of the traditional nations of world rugby, even under such circumstances, will be a huge incentive to them.