Twickenham makes its bow in this year’s championship by hosting this pivotal clash between two sides that are looking in good nick.
Ireland can claim the Triple Crown and take a giant step toward the Grand Slam if they can win at Twickenham for the first time since 2011, whereas England cannot lose if they are to keep their title hopes alive.
Ireland’s wealth of experience will provide a stern test for England’s young side. Can they deliver in front of an expectant home crowd, or will Ireland’s old heads win the day? It’s going to be fascinating.