With Spurs sitting in sixth, the North Londoners will be looking for a big away win to make up points on their rivals for their season's ultimate goal of a top-four finish and a place in next season's Champions League.
Meanwhile, Swansea will be hoping for a positive result to put a bit more space between them and the relegation spots, which loom just three points below the Welsh side, despite their place at 13th in the table.
While Tottenham picked up a 1-0 victory in the earlier meeting between these two sides, quite a lot has changed at White Hart Lane since that afternoon in August.
Since the firing of manager Andre Villas-Boas last month, Spurs have found a consistent attacking threat under new manager Tim Sherwood after an anemic 15 goals in their first 16 matches.
As one of the clubs that have altered their approach so much, it is hard to look back on the first match between these two for a clue for what to expect on the pitch Sunday.
So what will be the key matchups in this important encounter?
Here are the tactical battles that will shape Sunday's match between Swansea City and Tottenham Hotspur.