The match on August 17 will be Manuel Pellegrini’s first competitive game in charge at the Etihad Stadium, as the Magpies begin their season on the road.
The tie will see Newcastle start their campaign in Manchester for the second time in three years, following their opener at Old Trafford in 2010.
Incredibly, the clash will be the first time the two clubs have ever met on the first day of a new season.
Alan Pardew’s side suffered a disastrous trip to the blue half of Manchester last time out, going down 4-0 to City in March thanks to strikes from Carlos Tevez, David Silva and Vincent Kompany and an own-goal from James Perch.
And their away record in the Premier League against the Sky Blues makes for uncomfortable reading for Geordie fans, with just one win in 11 and five defeats in a row.
Newcastle’s first home game is on August 24 against Sam Allardyce’s West Ham. However, former Toon striker Andy Carroll could miss the match through injury despite being on the verge of sealing a move to the Hammers after passing a medical yesterday.
Allardyce will find himself in familiar territory having briefly managed the Toon in 2007-08. And he’ll also be hoping for a repeat of last season, where the Londoners snatched a 1-0 victory thanks to another former Magpie, Kevin Nolan.
Meanwhile, the first Tyne-Wear derby of next term will take place on October 26 at the Stadium of Light, where Newcastle will be looking to regain local bragging rights.
Despite finishing above Sunderland in the final Premier League table, defeat to the Black Cats back in April left the club’s supporters in shock, and revenge will be on the menu in a little over four months' time.
A welcome addition to the festive period is the visit of Stoke City on December 26, in a game that sees the Magpies play at home on Boxing Day for only the second time in 12 seasons.
Their season ends in the same manner as it begins, with a tough-looking fixture in the North West. Liverpool will provide the opposition on May 11 on Merseyside, with the Toon looking to record only their second Premier League victory at Anfield since the competition began in 1992.