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As detailed here, Manuel Pellegrini is the master of tactical adjustments—the man never stops learning.
He's famous for his 4-2-2-2 at Villarreal and Real Madrid, and he will always play two strikers if possible. Adept at training players at both ends of the field, he's not the kind of coach who sends out a mindless 4-4-2.
He produced a steely 4-2-3-1 this season at Malaga that proved incredibly tough to break down. Marco Reus and Co. of Borussia Dortmund had more joy against Real Madrid's Sami Khedira than they did against Malaga's Ignacio Camacho.
Anyone who manages to get Kaka, Raul, Rafael van der Vaart, Esteban Granero, Guti and Cristiano Ronaldo into the same lineup and not concede bucket-loads of goals deserves commendation.