The holders were slow and sloppy for the majority of the match and were made to pay as goals on either side of halftime from Samir Nasri and Sergio Aguero gave them too big of a hurdle to overcome. A Demba Ba strike on 66 minutes fired Chelsea back into the tie, but the momentum gained by the goal proved to be too little, too late.
There were some controversial decisions by referee Chris Foy. Aguero should have been shown a straight red card for a violent, two-footed assault on David Luiz's upturned bottom, whilst Fernando Torres' appeals for a penalty after a dramatic shirt pull in the box fell on deaf ears.
There was also debate around Rafa Benitez's decision to leave his two most experienced players, John Terry and Frank Lampard, on the bench for a crucial cup game, as both players had featured in the midweek trip to Moscow.
However, there is no doubt that City were the better side for the first 60 minutes as the Chelsea squad felt the fatigue from their fixture congestion.
Despite this, there were several Blues players who performed admirably, whilst others lacked their usual lustre. Here are the six winners and losers from this Chelsea team.
Statistics courtesy of whoscored.com