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The Warriors are not a small team. They have three legitimately sized centers in Andrew Bogut (7'0", 245 lbs), Festus Ezeli (6'11", 255 lbs) and Andris Biedrins (6'11", 240 lbs).
None of the three, however, are able to guard top-notch big men.
Bogut doesn't have the agility in his game right now to shut down athletic power forwards and centers. Ezeli is too young and inexperienced to stop skilled, clever bigs, and Biedrins is too weak to do anything about bulky bruisers down low.
While Mark Jackson may find a defensive matchup that works against one of your bigs, you'll give the Warriors defensive fits if you play two. Jackson cannot afford to play two centers at once as it will completely deaden his offense.
Therefore, you're guaranteed at least one great matchup if you roll out two bigs.
Draymond Green, Harrison Barnes, Klay Thompson, Richard Jefferson, Carl Landry and David Lee all provide decent athleticism and defensive effort, but none can hang with a low-post scorer.
Of course, you can't play two bigs all game. That's okay if you have a dominant 7'0", but minimize the time you spend going small.
If you do go small, Jackson will see it as an opportunity to play his incredibly dangerous offensive frontcourt of David Lee, Carl Landry and Klay Thompson. Playing multiple big men will deny Golden State from playing their best offensive unit.