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Sir Alex Ferguson is likely to rotate his team for Saturday's game, as his players continue to recover from a busy winter period.
According to the Scotsman, his team's chances against Chelsea were affected as "towards the end of the first half the players' legs were starting to go" (via ManUtd.com).
This being said, United will still be aware of complacency creeping in as they enter the final phase of the season.
With Brian McDermott having been sacked this week, caretaker boss Eamonn Dolan will be in charge of Reading's team selection at Old Trafford.
Expect the likes of Adam Le Fondre, Jobi McAnuff and Adrian Mariappa to keep their places in the first XI.
Manchester United: David de Gea, Rafael, Chris Smalling, Rio Ferdinand, Patrice Evra, Tom Cleverley, Anderson, Ashley Young, Wayne Rooney, Javier Hernandez, Robin van Persie.
Reading: Stuart Taylor, Stephen Kelly, Alex Pearce, Adrian Mariappa, Ian Harte, Mikele Leigertwood, Hope Akpan, Jobi McAnuff, Garath McCleary, Hal Robson-Kanu, Adam Le Fondre.