As the Champions League returns with the round of 16 clashes this week, Juventus and AC Milan will carry the hopes of Serie A as they look to extend their European journey.
The Bianconeri face Scottish champions Celtic, while Milan take on Spanish giants Barcelona as the duo look to qualify for the quarter-finals and beyond.
With such a rich history in the competition, Italians clubs have enjoyed a great deal of success in Europe's premier competition. Recent years haven't been too kind, but here are some of Serie A's greatest moments of all-time in the Champions League.
Dejan Savicevic, affectionately nicknamed "Il Genio", was the star of the 1994 final. Laying on Daniele Massaro's first, he went on to score a memorable long-range lob to down the Barcelona "Dream Team" in 1994.
Led by the attacking trio of Gianluca Vialli, Alessandro Del Piero and Fabrizio Ravanelli, Juventus sealed their place in Champions League history with a penalty shoot-out victory over Ajax.
The Bianconeri would go on to suffer European heartbreak thereafter, but memories of their win at the Stadio Olimpico in Rome will remain forever.
In 2003, it was guaranteed the trophy would be returning to Italy as AC Milan took on Juventus at Old Trafford in the final.
Although the game itself was somewhat a disappointment, ending 0-0, the penalty drama that followed resulted in the Rossoneri securing their sixth European trophy as Italy enjoyed a sense of European dominance.
After being inspired by Kaka to secure their place in the final at the expense of Manchester United, Milan went on to exact revenge on Liverpool in Athens after the heartbreak of Istanbul.
Two goals from Pippo Inzaghi meant a seventh European success for the Rossoneri, who withstood some late nerves to hold on.
Led by Jose Mourinho, Inter defeated Bayern Munich in the final to secure a historic treble after winning both the Scudetto and Coppa Italia.
Two goals from Diego Milito ensured the Nerazzurri parted company with the "Special One" on a victorious note, and ended an agonising wait to be crowned the champions of Europe.