Forget City. This is the big one. All the bitter rivalry and old wounds open up.
Sir Alex Ferguson has rightly tried to defuse the post Suarez-Evra situation but both will be playing on Sunday. Will we get the great handshake debate yet again?
These are England's two greatest clubs of all time, winning a total of 119 honours, which United just edge. They have met 186 times but United are ahead 73-62 on wins.
All of these stats make no difference on the day. Liverpool could be at the bottom of the Premier League and United at the top, but they would start equal in desire, passion and commitment.
Whether at home or away, however, the crowd is a major factor.
Whatever you do, don't miss the match. Watch all 90 minutes. It can be heart-stopping, anger-inducing and delight-inspiring, depending on the outcome.
Its tempo is more like a Cup match. Definitely one for the neutrals. Not for the fainthearted of either side.