The Chiefs also committed three turnovers and were unable to create any of their own, which turned out to be the biggest difference, despite a good game from the Chiefs running backs.
Here are the grades and analysis for the Chiefs.
Brady Quinn: F
When the Chiefs started Brady Quinn over Matt Cassel earlier this season, there was hope that he would decrease the turnover total. However, Quinn threw two interceptions on Sunday and could not throw for a touchdown. Out of the nine games Quinn has played this year, he has only thrown a touchdown pass in one of those games.
Jamaal Charles: A+
Despite the fact that Jamaal Charles fumbled in the red zone before halftime, he made up for it on the first play from scrimmage in the second half with an 86-yard touchdown run and finished with 226 yards.
Peyton Hillis: A
Peyton Hillis has struggled all season long, but he stepped up in this one to help the Chiefs when Charles took a breather on the sidelines. He finished with 101 rushing yards, his first 100-yard game in exactly a year.
Jon Baldwin: B-
Jon Baldwin had a nice catch-and-run that went for 57 yards early in the game. However, Baldwin was unable to make an impact outside of that.
Dexter McCluster: B
Dexter McCluster continues to get some touches through the air with the absence of Dwayne Bowe. But with no consistency from the quarterback, the Chiefs don't get to use McCluster's speed as much as they would like to.
Devon Wylie B
Devon Wylie didn't get much attention until today. He helped contribute to Kansas City's passing game and could get more looks in the season finale next week.
Steve Maneri: C
Steve Maneri had a nice catch as he broke a couple of tackles to pick up a first down. However, the play was called back due to a penalty. Maneri played well as a run-blocker to help the Chiefs running game run all over the Colts.
Donald Stephenson: C-
Donald Stephenson had a rough start to the game after being penalized for a holding and illegal use of the hands penalty. But he rebounded in the second half to build room for Charles and Hillis.
Jeff Allen: C
Jeff Allen was called for a crucial holding penalty early in the game after Charles ran for 17 yards to the Indianapolis 7-yard line. But like Stephenson, he improved and helped the running backs have a good day on the ground.
Ryan Lilja: B
Going up against his former team, Ryan Lilja played well for the most part. He had a couple of issues protecting Quinn, but still did well overall.
Jon Asamoah: B
The Chiefs drew up big runs mostly from the left, but Jon Asamoah played well and avoided having penalty flags being thrown his way.
Eric Winston: A-
Outside of one false start, Eric Winston did his job and contained pass-rushers to give Quinn what he needed to try to make a play.
Tyson Jackson: A
Tyson Jackson did a good job helping the outside linebackers create pressure, and he forced Andrew Luck to get rid of the ball sooner than he wanted to at times.
Donatri Poe: B
After a slow start to his rookie season, Dontari Poe's potential is slowly coming into fruition. He was able to come up with a couple of run stops as Vick Ballard had a 3.5 yards-per-carry average.
Ropati Pitoitua: B-
Ropati Pitoitua did well. The Colts had most of their good runs on the right side, but there weren't many.
Tamba Hali: A
Tamba Hali, as usual, showed up. Luck had few chances of making big plays because Hali chased him around. Luck spent more time than he wanted to dealing with the pressure applied by the Chiefs.
Justin Houston: B
Like Hali, Justin Houston made a big impact in the pass-rushing department to help hold the Colts below expectations.
Derrick Johnson: A
Derrick Johnson led the team in tackles, but he also helped the outside linebackers apply pressure and come up with huge run-stops to help bring the offense back out on the field.
Brandon Siler: B
Brandon Siler did a good job on Sunday helping the Chiefs limit Ballard, who has been very productive for the Colts this season.
Brandon Flowers: A
Brandon Flowers dealt with Coby Fleener and Donnie Avery a lot on Sunday. He didn't allow a big play and limited the pass-catchers he faced.
Javier Arenas: B
Javier Arenas didn't give up a big play either. He has done a good job filling in for Stanford Routt, who was released earlier this season.
Eric Berry: C
Eric Berry's most crucial error came in the final five minutes of the game, when Reggie Wayne went behind him and was wide open while catching the game-winning touchdown pass in the back of the end zone
Kendrick Lewis: B
Kendrick Lewis did a good job of helping the Chiefs cornerbacks by giving them safety help against receivers that Luck targeted.
Ryan Succop: C+
Ryan Succop connected nicely on a 47-yard field-goal attempt, but missed a 43-yarder later in the game. He has missed two of his four field-goal attempts in the last three games.
Dustin Colquitt: A
Dustin Colquitt is really the top highlight of the Chiefs special teams, which is a problem. It's nice that he's a good punter, but the Chiefs need a kick returner and more consistency from Succop.