In the first three matches in this rivalry, Marquez held tough but could not pull out a victory in any of them. The first installment ended in a draw, while the other two resulted in wins for Pacquiao.
Entering the fourth matchup, Dinamita needed to not only have a better performance than the ones he thought he won, but he needed to convince everyone that he was the best fighter in the ring.
Unfortunately, that was not the case for most of the fight.
Pacquiao came out aggressive, and like usual, he used his speed to throw a large number of punches early. In the first two rounds, he was easily landing the cleaner hits.
The third round was a little different, as Marquez knocked his opponent to the ground for the first time in this rivalry. It helped disorient the Pac-Man, but more importantly, it sent a message that he was serious.
However, this did not stand for long. Pacquiao went back on the attack, landing a flurry of power punches and eventually knocking down Marquez.
Through five rounds, all three judges had the Filipino boxer ahead 47-46 on their scorecards, according to Dan Rafael of ESPN. He was also very likely to win the sixth round after an impressive performance.
To make matters worse, Marquez had seemingly had a broken nose and was bleeding all over the place. The fight might have been stopped if it kept going in the same direction.
That is at least until Marquez came up with a huge right hand with only seconds remaining in the sixth round to knock out the former champ and come away with the upset.
Even though his counterpunching strategy is not always popular with judges, he stuck with it and it eventually paid off to help him get the biggest strike of his life.
The Mexican fighter was taking everything that Pacquiao threw at him. Pac-Man landed 46 percent of his power punches in the bout, compared to only 27 percent by Marquez (via ESPN).
Still, Marquez stayed in the match and eventually did what was necessary to get the win.
His resolve helped him stay in the match after falling behind, and it helped him in his career after two close losses to the same person.
The veteran proved that he is one of the best fighters of his generation, and his determination should be an example for others around the world of what can happen when you stick with something.