The Spurs shot 55 percent from the field in route to a 114-92 drubbing of the Rockets.
Tim Duncan came through with a double-double for San Antonio, scoring 12 points and 12 rebounds, including two offensive.
Tony Parker and Gary Neal combined for 29 points and nine assists as the Spurs went 12-of-13 at the charity stripe and out-rebounded the Rockets 50-37.
The biggest discrepancy of the night?
San Antonio's 60 points in the paint to Houston's 38.
James Harden was the leading man for the Rockets, netting 29 points while shooting 50-percent or better from field goal range and beyond the arc.
As a team, the Rockets shot just 39 percent from the field and saw three of its five starters combine for a mere 11 points.
Player of the Game: Tiago Splitter
Splitter came off the bench for San Antonio to score 15 points on 6-of-7 shooting in 20 minutes of play.
He also contributed six rebounds, two assists and a block, sporting a +24 efficiency rating on Friday night.
That's now back-to-back games that Splitter has scored 15 points and grabbed at least five rebounds.
What's Next for Houston?
The Rockets will need a case of amnesia after tonight, as Houston will take on the Dallas Mavericks (9-10) at home on Saturday night at 8 p.m. ET.
What's Next for San Antonio?
There's no time to rest for the Spurs, as they'll travel to Charlotte to take on the 7-10 Bobcats on Saturday night at 7 p.m. ET.
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