This game will prove as a reunion of sorts for several of KC's staff and players.
Head coach Romeo Crennel, offensive coordinator Brian Daboll, quarterback Brady Quinn and running back Peyton Hillis all used to be members of the Browns organization.
Here are five Chiefs to watch for in this game.
The Kansas City signal-caller is coming off of one the best games of his pro career. Quinn is looking to add to that with a solid performance against Cleveland this week.
Quinn threw for 201 yards and two touchdowns in the Chiefs' big victory over Carolina last week.
This week, he will face a Browns defense that struggles against the pass, so he should have every opportunity to have another good game.
Quinn will be playing with extra motivation, since he used to played for Cleveland from 2007-09.
Jamaal Charles is one of the best backs in the NFL today.
His 1,055 rushing yards are good for No. 6 in the league and he has rushed for 100-plus yards in two out of his last three contests.
Once again, Charles will likely be called upon to be the catalyst for KC's rushing attack. His ability to make plays in the running game will help set up the play action for Quinn.
The former Texas Longhorn will need to play well this week if Kansas City is going to pick up its third win of the year.
When the Chiefs signed ex-Brown Peyton Hillis last offseason, they thought that he would be a solid complement to Pro Bowl RB Jamaal Charles.
Instead, he has been a major disappointment.
Just like his teammate Brady Quinn, he could have an extra chip on his shoulder since he is playing against his former team this weekend.
The comments that were made by Browns offensive lineman Joe Thomas may have Hillis fired up, so we'll see how he responds in this game.
KC starting defensive end Tyson Jackson is coming off arguably the best three-game stretch of his NFL career.
He has been playing like a man possessed and it is slowly starting to rub off on some of his teammates along the defensive line.
Jackson has racked up 13 tackles, two sacks and has been a force against the run over the three-game span.
This week Jackson has another opportunity to prove he is getting better and to start shaking off the bust label that many have already given him after being drafted third overall in 2009.
Like many others Chiefs last week, inside linebacker Brandon Siler was playing with a heavy heart.
After all, Siler was getting his first start ever as a Chief, playing in place of Jovan Belcher, who tragically took his girlfriend's life before committing suicide outside of the Chiefs' practice facility last Saturday.
All eyes will be on Siler this week as he makes his second start at Belcher's old spot.