Sir Alex Ferguson’s men travel to the Etihad Stadium with a three point advantage of the champions, who hope to build on two successive victories over the Reds last season.
Victory would provide a huge shot in the arm to either side’s title ambitions and would go a long way to appeasing the fans, who have been slightly critical of both teams this campaign.
Quite simply, this weekend’s 163rd Manchester derby is the biggest since, well, the last one. Which got us thinking: Which are the most memorable encounters between these two great clubs?
Here, I assess the options and recall five classic battles between City and United.