Cristiano Ronaldo will return to Manchester for the first time since playing for Manchester United in 2009.
For the second time in two years, Manchester City is staring into the eyes of elimination at the Champions League group stage.
Man City is last in Group D, collecting just two points so far in their matches. They will have to win against Real Madrid and also Borussia Dortmund if they want any chance at staying alive. Only two teams have ever recovered from such a position (Lokomotiv Moscow in 2002 and Porto in 2004).
Real Madrid is another story. Madrid is currently second behind Borussia Dortmund. Madrid also has a 3-2 win over Man City under its belt, coming back in September. With Madrid standing just one point behind Dortmund, they can secure advancing to the next stage with room to spare with a win over Man City on Wednesday.
Where: Ethiad Stadium, Manchester, England
When: Wednesday, November 21, 2:45 p.m. EST
TV: Fox Soccer Channel
Live Stream: Fox Soccer2Go
Real Madrid: Can They Play Well and Avoid an Upset?
This game is Real Madrid's to lose. Man City has a plethora of injured players and has struggled in Champions League play. However, City's home record against Spanish clubs is 2-0-1. Real Madrid will have to play a solid game to defeat Man City in England.
Who will win?
The most important aspect of this game for Real Madrid is Cristiano Ronaldo. The Portuguese will be a tall task for City. Manager Robert Mancini's game plan for Ronaldo? "Call the Police."
According to The Sport Review, Mancini is hoping for an off night for Ronaldo in the superstar's return to Manchester, and jokingly said he's willing to pull out all the stops to contain the star, even if it means getting the law involved.
This will be Ronaldo's first return to Manchester since leaving Manchester United in 2009.
Manchester City: Can They Overcome Injuries and Stop Cristiano Ronaldo?
Man City has the odds stacked against them before this game even starts. Volatile superstar Mario Balotelli is doubtful with back issues, Gael Clichy is out with an ankle injury and defender Micah Richards will be out with a knee injury.
City will have to use their thin roster to stop a red hot Cristiano Ronaldo. City's former cross-town rival has found the net 14 times in his last 11 Champions League matches. In Ronaldo's time with Manchester United he scored four goals against City, and was sent off twice.
City will have to overcome their injuries and play well against Ronaldo if they hope to advance to the next stage.
Prediction: Real Madrid wins 3-1, with Ronaldo netting at least one goal.