ESPN's College GameDay will be in Eugene on Saturday, as the Stanford Cardinal (8-2) take on the Oregon Ducks (10-0) inside Autzen Stadium, with the opening kickoff scheduled for 8:00 p.m. ET on ABC.
The Cardinal are currently 20.5-point road underdogs in the Week 12 college football betting odds (courtesy of SBR Forum), while the total has settled in at 64.5.
Let's take a closer look at this Pac-12 Conference matchup from a betting perspective, while offering an against-the-spread (ATS) pick along the way.
The Stanford Cardinal have a great chance to improve upon their 11-3-1 ATS record on the road since 2010, as they've covered both opportunities as an underdog during the 2012 campaign.
Sports bettors will also be enthused by the Cardinal leading the nation in rush defense, as they prepare for one of the best offenses in the history of college football.
The Oregon Ducks own the nation's longest win streak at 13 games, as they've set an NCAA record for scoring 42 or more points in each of those contests dating back to last year.
Sports bettors need to be cautious in laying this type of number, considering the Ducks are 1-7 ATS before playing the Oregon State Beavers.
I reached out to Jimmy Vaccaro earlier this week about this high-profile affair. He serves as the public relations director for William Hill U.S., and here's what he had to say:
This may be the week Oregon stubs its toe a little bit with its rash of injuries. I still say they win, but it won't be by more than two TDs.
I'm going to recommend that readers back the Stanford Cardinal in this high-profile affair, but they should only get involved if the point spread moves back to 21 or more points in favor of the Oregon Ducks.
College Football Week 12 Pick: Stanford Cardinal +21 or higher