1. With all four No. 1 seeds advancing to the Final Four for the first in tourney-history in 2008, can the defending NCAA champion No. 3 seed Kansas Jayhawks, the Psycho-T -led and Ty Lawson-toe-less No. 1 seed North Carolina Tar Heels, a sleeper No. 6 UCLA Bruins and a snubbed No. 2 Memphis Tigers, all meet again in the 2009 Final Four?
2. Can this years three No. 1 seeds from the Big East—the Pittsburgh Panthers, UConn Huskies, Louisville Cardinals—all march on to more madness in the Motor City, 24 years after the Big East sent three teams—Georgetown Hoyas, Villanova Wildcats, and St. Johns to the Final Four?
3. After multiple 30 plus wins seasons, will John Calipari coach his snubbed No. 2 Memphis Tigers back to the Final Four and prove the selection committee wrong—his team deserved a No. 1 seed?
4. How is it the largest city in America, the Mecca of basketball on any college, high school, street ball or pro level—New York City—have no local teams in the tourney for the third-straight year?
5. Eleven years since their last March Madness bid, will Manny Harris and the Michigan Wolverines be Manny Harris and Michigan Wolverines or will second-year head coach John Beilein be tourney-savvy head coach John Beilein: A coach who makes Big Blue fans forget about who—Rich Rodriguez—coaches the football team and grateful for a fabulous first round win over the Clemson Tigers?
6. Will UConn Huskies college men's and women's basketball head coaches, Jim Calhoun and Geno Auriemma respectively, each earn his pay and who will their lead their No. 1 seed deeper in the big dance?
7. Wast the disrespected SEC, with a No. 8 LSU Tigers team who won the conference by three games, a No. 9 Tennessee Volunteers who played eight non-conference games—No. 9 Siena (won), No. 10 Gonzaga (lost twice), No. 11 Temple (lost), No. 3 Kansas (lost), No. 2 Memphis (lost)—and a No. 13 Mississippi State that shot 36 percent and missed 21 three-pointers in their automatic-bid win in the SEC tournament, really that disrespected?
8. The seven overtimes in the Big East tournament earned the Syracuse Orange a No. 3 seed for the first time since Carmelo Anthony led them to the 2003 National Championship, but will this years Jim Boheim teams' legs feel too heavy and their shots fall too short enough to dance their way past the Sweet 16?
9. Can the Buckeye state with five teams—No. 13 Akron, No. 8 Ohio State, No. 4 Xavier, No. 11 Dayton, and No. 13 Cleveland State—send one team to the Final Four in Michigan and what will happen to the depressed Wolverine fan when they do?
10. How will Kentucky fans cope with a year out of the Big Dance when their former head coach Tubby Smith has No. 10 Minnesota Golden Gophers eying a Texas-sized upset over the No. 7 Longhorns and playing for a Sweet-16 birth?
11. Can Coach Mike Krzyzewski lead the No. 2 Duke Blue Devils back to the Final Four and win his fourth National Championship, the most of any other coach in the sport's history?
12. Can Tony Kornheiser's alma mater, the No. 15 Binghamton Bearcats, playing in their first-ever NCAA tourney game, upset the No. 1 Duke Blue Devils playing in their 33rd NCAA tournament?
13. After losing 67-62 to the No. 9 Texas A&M Aggies in the first round of last year's tournament, can the No. 8 BYU Cougars survive an Aggies' recent tournament success and advance to play the No. 1 Connecticut Huskies?
14. Can a Cinderella No. 12 Arizona Wildcats' team, not coached by Lute Olsen, advance over No. 5 Utah?
15. For the first time in 34 years, Billy Packer will not be calling the Final Four games this year, will the duo of Clark Kellogg and Jim Nance outshine the Packer's finest moments?
16. In the championship game at Ford Field, will the home team finally win a game in Detroit?