In the case of Jordy Nelson and Randall Cobb, it's man down, man up.
Nelson, who finished 2011 as the NFL's No. 2 fantasy wideout, has struggled to duplicate last season's magic, and any hope that he would rebound this week against the Arizona Cardinals took a big hit in the first quarter.
According to ESPN's John Clayton, the fifth-year wideout suffered an ankle injury and is questionable to return.
With Nelson down and perennial No. 1 receiver Greg Jennings sidelined after undergoing surgery for a torn abdominal muscle, the onus falls on second-year man Randall Cobb to become the Packers' top fantasy and real-life receiver.
If Sunday has any bearing on the rest of the season, Cobb will get the job done.
Almost on cue, the dynamic playmaker scored a 13-yard touchdown just minutes after Nelson exited the game.
While it's always unfortunate to see a good guy like Nelson bitten by the injury bug, his absence should open up the door for Mike McCarthy to highlight Cobb as the Packers' new go-to guy.
Unlike Nelson—who stands 6'3", 217 pounds—Cobb makes his money with elite agility, balance and run-after-the-catch skills.
Already one of the best return men in the game, Cobb has slowly shown just how dangerous a weapon he can be on offense as his role has increased this year.
As of the second quarter of Green Bay's matchup against Arizona, the former Kentucky Wildcat has recorded 43 receptions for 476 yards and five touchdowns, and returned one punt for a touchdown.
No one knows the extent of Nelson's ankle injury yet, but it's safe to say he probably won't be at 100 percent in the near future, considering he was already battling a hamstring problem.
However, with James Jones playing the best football of his career, defenses won't be able to devote all their attention to the dangerous Cobb.
Barring injury, the former second-round pick should be the Packers' version of Percy Harvin, and far and away the top Packers fantasy receiver to own for the second half of the season.