Statistics don't lie and if past encounters are anything to go by, Arsenal should be a very worried team as they head to Old Trafford this weekend.
I don't expect a repeat of last season's 8-2 scoreline, but it did mark United's third consecutive win in the fixture.
In fact, United have only lost once in the last decade and with the form and fitness of key players certainly siding in the Red Devils' favour, it takes a brave man to predict anything other than a home win.
However, Arsenal are certainly no pushovers and showed what they're made of with a stunning comeback in the Capital One Cup on Wednesday at Reading.
The world will be watching as Robin van Persie lines up against the club that made him a star.
Will he come back to haunt Arsene Wenger? Sir Alex will be hoping Halloween extends for a little longer come 12: 45 p.m. on Saturday.
Here's six things United must get right if they are to win...