Michigan's main concern as it prepares for Saturday's matchup is the health of quarterback Denard Robinson.
The senior signal-caller re-injured a nerve in his throwing elbow late in the first half of last week's 23-9 loss at Nebraska, but is expected to start Saturday.
"We're planning on it," said head coach Brady Hoke at his Wednesday press conference. "He's better. It's not all the way cleared up yet, but it's better."
Should Robinson not be able to start, Hoke will most likely turn to Devin Gardner, who has spent this season as one of Michigan's primary pass receivers.
Last week Russell Bellomy took over for Robinson, but he was only able to complete three of 16 passes along with three critical interceptions.
Devin Gardner, who's been Robinson's backup in the past and moved to wide receiver this season, will most likely be the quarterback Saturday if Robinson can't play. Gardner has taken more than his share of snaps at practice this week.
With this in mind, USA Today has listed Michigan as 12.5-point road favorites to retain the Little Brown Jug, the trophy awarded to the game's winner since 1903.
Michigan won last year's game in Ann Arbor, 58-0, and leads the overall series 71-24-3.
Let's look at the five keys necessary for Michigan to leave Minnesota with the trophy.