Sir Alex Ferguson has already stated that he will field a very different team to the league game for the upcoming tie. As is normal for Ferguson's team selection in this competition, one can expect a mix of youngsters from the reserve team to play alongside some senior members in need of some game time.
With Chelsea still smarting over the controversial nature of their defeat to United on Sunday, this game may have all the intensity and rancor associated with a Premier League match between these giants of English football. As things stand, it will be a stern test for whichever players Ferguson decides to select for the game.
Here is a look at five players who are likely to play on Wednesday and who will have the biggest point to prove in the upcoming game.