By the time Oscar was able to pull back a goal for Chelsea in the 88th minute on Tuesday night, it was already too late.
Two earlier goals from Alex Teixeira and Fernandinho had already ensured an important home victory for Shakhtar Donetsk, 2-1.
It is a big loss for a Chelsea team who has become unaccustomed to losing this season, and many are already calling it a major dent in the Blues' hopes of retaining the Champions League trophy.
There is no denying that it is a match that Roberto Di Matteo would have expected his team to win.
But is it a shock upset? Far from it.
In fact, here are a few reasons to look on the bright side following Chelsea's loss.