It's extremely difficult to do a "Winners-and-Losers" article when you cannot find more than a single player who qualifies as a winner.
For those of you keeping score at home, the Bills have been outscored 90-17 in the last six quarters.
It's one thing to allow Tom Brady and the Patriots march up and down the field on you, but Alex Smith? Regarded by his detractors as a "game manager", Smith averaged 12.6 yards per throw against the Bills.
Alex Smith wasn't the only player who had a great game against Buffalo. The 49ers rushing attack ran for over 300 yards and two of their receivers went over 100 yards.
As you can see, there is plenty of blame to go around. With that, let's take a look at which Bills players need to be singled out for their horrendous play and which deserve some positive recognition.